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When a catastrophic collision between realities tears the Marvel Universe apart, heroes and villains from across the multiverse are thrown together in a desperate battle for survival. As the worlds of heroes such as Spider-Man, Iron Man, Doctor Strange, Black Panther, and the Guardians of the Galaxy collide with their most dangerous enemies, alliances are formed and broken as each faction fights to control the fate of reality itself. With the fabric of existence unraveling and alternate versions of familiar faces emerging from the chaos, Earth's greatest heroes must overcome their differences—and each other—to stop a multiversal catastrophe before countless worlds are destroyed.